Extended indication Thymidine Kinase 2 (TK2) Deficiency
Therapeutic value No estimate possible yet
Registration phase Clinical trials

Product

Active substance Deoxythymidine/deoxycytidine
Domain Neurological disorders
Reason of inclusion New medicine (specialité)
Main indication Muscular diseases other
Extended indication Thymidine Kinase 2 (TK2) Deficiency
Manufacturer Zogenix
Route of administration Oral
Budgetting framework Extramural (GVS)

Registration

Registration route Centralised (EMA)
Submission date 2022
Expected Registration 2023
Registration phase Clinical trials

Therapeutic value

Therapeutic value No estimate possible yet
Substantiation Momenteel zijn er alleen open label studies gaande wat het lastig maakt om een goede therapeutische waarde in te schatten.
Dosage per administration 400 mg/kg/day
References NCT04581733

Expected patient volume per year

Patient volume

< 10

Market share is generally not included unless otherwise stated.

References TK2-Related Mitochondrial DNA Maintenance Defect, Myopathic Form. Julia Wang. 2012 (1); expertopinie (2)
Additional comments Een zeer zeldzame ziekte, 107 gevallen bekend wereldwijd (1). In Nederland is de inschatting dat er maximaal 10 patiënten zouden kunnen zijn maar waarschijnlijk minder (2).

Expected cost per patient per year

There is currently nothing known about the expected cost.

Potential total cost per year

There is currently nothing known about the possible total cost.

Off label use

There is currently nothing known about off label use.

Indication extension

There is currently nothing known about indication extensions.

Other information

There is currently no futher information available.