Extended indication

Generalized Myasthenia Gravis

Therapeutic value

No estimate possible yet

Registration phase

Registration application pending


Active substance



Neurological disorders

Reason of inclusion

New medicine (specialité)

Main indication

Muscular diseases other

Extended indication

Generalized Myasthenia Gravis



Portfolio holder


Route of administration


Therapeutical formulation


Budgetting framework

Extramural (GVS)

Centre of expertise

LUMC / MUCM+ / AUMC (loc. AMC)

Additional remarks
Mechanism of Action:  zilucoplan is a synthetic macrocyclic peptide inhibitor of the terminal complement protein C5, with potential anti-inflammatory and cell protective activities. Upon subcutaneous administration, complement inhibitor zilucoplan binds to a unique site in terminal complement protein C5, which blocks C5 cleavage into C5a and C5b and prevents the C5b-dependent assembly of the membrane-attack complex (MAC). Zilucoplan also inhibits the interaction between C5b and C6, thereby further blocking MAC assembly.


Registration route

Centralised (EMA)

Type of trajectory

Normal trajectory



Submission date

September 2022

Expected Registration

October 2023

Orphan drug


Registration phase

Registration application pending

Additional remarks
submission date expected late second half of 2022

Therapeutic value

Current treatment options

Cholinesterase inhibitors, corticosteroids, Immunosuppressants, Intravenous, Immunoglobulins, bloodplasma transfer, Rituximab, Eculizumab

Therapeutic value

No estimate possible yet


Fase 2 studie afgerond. In vergelijking met placebo laat het geneesmiddel positieve resultaten zien (1). Een fase 3 studie zou verder uitsluitsel moeten geven over de therapeutische waarde van dit geneesmiddel ten opzichte van andere beschikbare geneesmiddelen (2). Op basis van de beschikbare data wordt op dit moment verwacht dat de nieuwe complementremmers ongeveer gelijk zullen presteren aan eculizumab.

Frequency of administration

1 times a day

Dosage per administration


Howard JF Jr, Nowak RJ, Wolfe GI, et al. Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial. JAMA Neurol. 2020;77(5):582-592. doi:10.1001/jamaneurol.2019.5125, (NCT03315130, fase 2) (1), Studie-opzet fase 3-studie (NCT04115293) (2); NCT03971422)

Expected patient volume per year

Patient volume

< 1,750

Market share is generally not included unless otherwise stated.

1) Spierziekten Nederland;
Additional remarks
In Nederland wordt de prevalentie van gegeneraliseerde Myasthenia Gravis (gMG) patiënten geschat op 1 op 10.000 inwoners. Dit komt overeen met 1.750 patiënten uitgaande van 17,5 miljoen inwoners (1).

Expected cost per patient per year

There is currently nothing known about the expected cost.

Potential total cost per year

There is currently nothing known about the possible total cost.

Off label use

There is currently nothing known about off label use.

Indication extension

There is currently nothing known about indication extensions.

Other information

There is currently no futher information available.