Extended indication Gastric or Gastro-oesophageal Junction Adenocarcinoma (GC/GEJC). Imfinzi in combination with FLOT chemotherapy as neoadjuvant and adjuvant treatment,
Therapeutic value No estimate possible yet
Registration phase Registered

Product

Active substance Durvalumab
Domain Oncology
Reason of inclusion Indication extension IND
Main indication Stomach cancer
Extended indication Gastric or Gastro-oesophageal Junction Adenocarcinoma (GC/GEJC). Imfinzi in combination with FLOT chemotherapy as neoadjuvant and adjuvant treatment, followed by adjuvant Imfinzi monotherapy, is indicated for the treatment of adults with resectable gastric or gastro‑oesophageal junction adenocarcinoma.
Proprietary name Imfinzi
Manufacturer AstraZeneca
Portfolio holder AstraZeneca
Mechanism of action PD-1 / PD-L1 inhibitor
Route of administration Intravenous
Therapeutical formulation Intravenous drip
Budgetting framework Intermural (MSZ)

Registration

Registration route Centralised (EMA)
Type of trajectory Normal trajectory
ATMP No
Submission date July 2025
Expected Registration March 2026
Orphan drug No
Registration phase Registered
Medicine sluice Broadly excluded
Additional remarks Positieve CHMP-opinie in januari 2026.

Therapeutic value

Current treatment options nivolumab, atezolizumab, pembrolizumab, trastuzumab
Therapeutic value No estimate possible yet

This assessment does not indicate any potential inclusion in the package.

Substantiation De tweejarige event-free survival (Kaplan-Meier schatting) was 67,4% in de durvalumab-groep en 58,5% in de placebogroep, met een hazard ratio van 0,71 (95% BI, 0,58 tot 0,86; P<0.001). De tweejarige overall survival was 75,7% in de durvalumab-groep en 70,4% in de placebogroep. De piecewise hazard ratio voor overlijden was 0,99 (95% BI, 0,70 tot 1,39) voor de eerste 12 maanden en 0,67 (95% BI, 0,50 tot 0,90) voor de periode daarna, met een P-waarde van 0,03. Deze resultaten kunnen door cieBOM beoordeeld worden, als het geneesmiddel is geregistreerd. Het is nog onduidelijk of het aan de PASKWIL criteria zal voldoen.
References NCT04592913 (MATTERHORN); https://meetings.asco.org/2024-asco-gastrointestinal-cancers-symposium/15568?presentation=229135#229135

Expected patient volume per year

Patient volume

Market share is generally not included unless otherwise stated.

References NKR2021 (1); expertopinie (2)
Additional remarks De incidentie van maagcarcinoom betrof 1.109 (1. Het merendeel wordt geopereerd. Diegene die progressie hebben, vallen af (maximaal 25% valt af) (2).

Expected cost per patient per year

Potential total cost per year

Off label use

Indication extension

Other information