Gepubliceerd op 9 januari 2018

Cardiovasculaire aandoeningen

• Allogenic immunomodulatory progenitor cells
• Anacetrapib
• Andexanet alfa
• Autologous stem cells
• Betrixaban
• Canakinumab
• Caplacizumab
• Ciraparantag
• Evolocumab
• Human fibrinogen / Human thrombin
• Prasugrel
• Rivaroxaban
• Ularitide
• Valsartan / sacubitril
• Vonicog alfa

Chronische immuunziekten

• Abatacept

• Adalimumab

  • Humira is bestemd voor de behandeling van juveniele chronische niet-infectieuze uveitis anterior bij patiënten vanaf twee jaar die een ontoereikende respons hebben gehad op conventionele behandeling of deze niet verdragen, of voor wie conventionele behandeling niet geschikt is.
  • RA, juvenile idiopathic arthritis, axial spondyloarthritis, psoriatic arthritis, psoriasis, pediatric plaque psoriasis, adult and adolescent hidradenitis suppurativa, Crohn’s disease, pediatric Crohn’s disease, ulcerative colitis, uveitis
  • RA, polyarticular juvenile idiopathic arthritis, active psoriatic arthritis, active ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis

• Alicaforsen

  • Pouchitis
  • Ulcerative colitis (UC)
• Avacopan
• Baricitinib
• Budesonide
• Certolizumab pegol
• Dupilumab
• Expanded human allogenic mesenchymal adult stem cells extracted from adipose tissue
• Forigerimod (Rigerimod)
• Guselkumab
• Icatibant
• Ixekizumab
• Lesinurad / allopurinol
• Masitinib
• Nemolizumab
• Remestemcel-L
• Rifaximin
• Risankizumab
• Sirukumab
• Tildrakizumab
• Tocilizumab

• Tofacitinib

  • Ulcerative colitis
  • Xeljanz, in combination with a csDMARD, is indicated for the treatment of active PsA in adult patients who have had an inadequate response or who have been intolerant to a prior DMARD therapy (indicatie onder voorbehoud EMA proces)
• Upadacitinib

Infectieziekten

• Amoxicilline / omeprazol / rifabutin
• Benznidazole
• Bictegravir / emtricitabine / tenofovir alafenamide fumaraat
• Cadazolid
• Darunavir / cobicistat / emtricitabine / tenofovir alafenamide
• Dolutegravir /rilpivirine
• Emtricitabine / tenofovir disproxil fumarate
• Eravacycline
• Glecaprevir / pibrentasvir
• Letermovir
• Liposomaal amikacine
• Meropenem / vaborbactam
• Omadacycline
• Ozenoxacine
• Peramivir
• Recombinant vaccin voor meningokokken groep B
• Recombinant zoster vaccin
• Sofosbuvir / velpatasvir / voxilaprevir

Longziekten algemeen

• Alpha-1-antitrypsin
• Benralizumab
• Dupilumab
• Fluticasone furoate / umeclidinium (bromide) / vilanterol (trifenatate)
• Glycopyrrolate / formoterol

• Mepolizumab

  • COPD
  • Eosinofile granulomatueze poly angiitis (EGPA) (voorheen Churg Strauss syndroom).
• Tezacaftor / ivacaftor
• Tiotropium bromide
• Tralokinumab

Neurologische aandoeningen

• Biotin

• Botulinum A toxin

  • Chronic sialorrhoea in adults and children, associated with neurological conditions (Parkinson’s Disease (PD), stroke, traumatic brain injury (TBI), cerebral palsy (CP).
  • Lower limb spasticity (LLS), in adults post stroke or traumatic brain injury (TBI).
  • Lower limb spasticity (LLS), post stroke.
• Brexpiprazole
• Cariprazine (hydrochloride)
• Cenegermin

• Ciclosporin

  • Keratoconjunctivitis sicca (or dry eye disease), moderate-to-severe and specifically in patients with atopic keratoconjunctivitis.
  • Treatment of severe vernal keratoconjunctivitis in children from 4 years of age and adolescents.
• Cladribine
• CM-AT / CM-4612
• Eculizumab
• Eptinezumab
• Erenumab

• Esketamine

  • Therapie resistente depressie.
  • Tinnitus.
• Eteplirsen
• Galcanezumab
• Idebenone

• Leuco-methylthioninium

  • Alzheimer’s disease, mild-to-moderate.
  • Dementia, behavioural variant frontotemporal.
• Lurasidone

• Masitinib

  • Amyotrophic lateral sclerosis (ALS), add on in patients on a stable dose of riluzole.
  • Multiple sclerosis, primary-progressive or relapse-free secondary progressive (SPMS); PPMS; Alzheimer's disease, 1L.
• Melatonin
• Mexiletine HCl
• Nusinersen
• Ocrelizumab
• Ozanimod
• Patisiran
• Pimavanserin
• Pitolisant
• Siponimod
• Tasimelteon
• Valbenazine
• Vigabatrin
• Voretigene neparvovec

Oncologie en Hematologie

• Abemaciclib
• Abiraterone
• Afatinib
• Alectinib
• Anamorelin

• Atezolizumab

  • Borstkanker (triple negative BC).
  • Gastric cancer
  • NSCLC non-squamous 1st line.
  • Renal cell carcinoma (RCC), advanced, unresectable - first-line in combination with axitinib.
  • Tecentriq is als monotherapie geïndiceerd voor de behandeling van volwassen patiënten met lokaal gevorderd of gemetastaseerd urotheelcarcinoom (UC) na eerdere behandeling met platina-bevattende chemotherapie of voor wie cisplatine ongeschikt is.
  • Tecentriq is als monotherapie geïndiceerd voor de behandeling van volwassen patiënten met lokaal gevorderde of gemetastaseerde niet-kleincellige longkanker (NSCLC) na eerdere behandeling met chemotherapie. Patiënten met EGFR-activerende mutaties of ALK-positieve mutaties moeten ook doelgerichte behandeling hebben ontvangen voor ze Tecentriq krijgen.

• Avelumab

  • Bavencio is geïndiceerd als monotherapie voor de behandeling van volwassen patiënten met gemetastaseerd merkelcelcarcinoom (MCC).
  • Treatment of locally advanced unresectable, metastatic or recurrent non-small cell lung cancer (NSCLC) after prior chemotherapy in adults, 2L.
• Axicabtagene ciloleucel
• Binimetinib

• Blinatumomab

  • Adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukaemia (ALL).
  • Relapsed / Refractory Ph+ Adult Acute Lymphoblastic Leukemia (ALL).
  • Relapsed / Refractory precursor-B Acute Lymphoblastic Leukemia (ALL) in children.
• Bosutinib
• Brain cancer vaccine
• Brentuximab vedotin
• Brigatinib
• Cytarabine / daunorubicin (liposomaal)
• Damoctocog alfa pegol
• Dasatinib
• Denosumab
• Depatuxizumab mafodotin
• Durvalumab

• Durvalumab / Tremelimumab

  • First line bladder cancer.
  • Head and neck (or upper airways tract) cancers; squamous cell carcinoma of head or neck (SCCHN), 2L Durvalumab monotherapy in PDL1-positive tumours or in combination with Tremelimumab for PDL1-negative tumours.
  • Non-small cell lung cancer (NSCLC) stage IV, in combination with tremelimumab, 1L.
• Emicizumab
• Encorafenib
• Fulvestrant
• Gemtuzumab ozogamicin

• Ibrutinib

  • Chronische graft-versus-host disease
  • Follicular lymphoma (FL), relapsed / refractory.
  • Mantle cell lymphoma (MCL), 1L.
  • Marginal zone lymphoma (MZL), relapsed / refractory.
  • Non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL), 1L.
• Idelalisib
• Inotuzumab ozogamicin
• Ipilimumab
• Lutetium-177
• MABp1
• Masitinib
• Midostaurin
• Neratinib
• Nilotinib
• Nintedanib
• Niraparib (tosylate monohydrate)

• Nivolumab

  • Adjuvant melanoma stage III - post-resection adjuvant therapy in high-risk patients.
  • Hepatocellular carcinoma after sorafenib (liver cancer)
  • Mesothelioom (in combinatie met ipilimumab).
  • Metastatic colorectal carcinoma with mismatch-repair deficient (dMMR) microsatellite instability–high (MSI-H).
• Obinutuzumab

• Olaparib

  • Metastatic breast cancer with gBRCA1/2 mutations - monotherapy in patients who have previously received treatment with anthracycline and taxane and are suitable for single-agent chemotherapy.
  • Metastatic pancreatic cancer, gBRCA mutated - maintenance monotherapy in adults whose disease has not progressed on first line platinum based chemotherapy.
  • Prostate cancer - monotherapy for BRCA 1/2 or ATM gene-mutated metastatic castration resistant prostate cancer (mCRPC) in patients who have received a prior taxane-based chemotherapy and at least one newer hormonal agent (abiraterone or enzalutamide).
  • Tabletten ipv capsules voor onderhoudsbehandeling platinum sensitief recidief ovariumcarcinoom.
• Osimertinib
• Paclitaxel
• Padeliporfin

• Pembrolizumab

  • 1st line non-squamous NSCLC in combination with platinum-pemetrexed.
  • Adjuvant melanoma stage III - post-resection adjuvant therapy in high-risk patients.
  • Breast cancer, metastatic triple negative.
  • Head & Neck cancer.
  • KEYTRUDA als monotherapie is geïndiceerd voor de behandeling van lokaal gevorderd of gemetastaseerd urotheelcarcinoom bij volwassenen die eerder platinumbevattende chemotherapie hebben ondergaan. KEYTRUDA als monotherapie is geïndiceerd voor de behandeling van lokaal gevorderd of gemetastaseerd urotheelcarcinoom bij volwassenen die niet in aanmerking komen voor cisplatinebevattende chemotherapie.
  • Locally advanced or metastatic gastric and gastroesophageal junction adenocarcinoma - second- and subsequent-line.
  • Multipel Myeloma
• Plitidepsin
• Ramucirumab
• Regorafenib

• Ribociclib

  • Breast cancer, advanced metastatic, HR+ and HER2-, in combination with fulvestrant, postmenopausal women and men, 1L en 2L
  • Breast cancer, advanced metastatic, HR+ and HER2-, in combination with tamoxifen and goserelin or a non-steroidal aromatase inhibitor (NSAI) and goserelin, premenopausal women.
• Rociletinib
• Romiplostim
• Ropeginterferon alfa-2b
• Rovalpituzumab tesirine
• Rucaparib
• Rurioctocog alfa pegol
• Sunitinib
• Telotristat etiprate

• Tisagenlecleucel

  • Diffuse Large B-Cell Lymphoma (DLBCL): relapse and/or refractory patients, not eligible for SCT (3L).
  • Paediatric Acute Lymphatic Leukeamia (ALL): relapse and/or refractory patients, not eligible for SCT (3L).
• Trastuzumab

• Veliparib

  • Breast cancer; early-stage triple-negative - neoadjuvant therapy with carboplatin
  • Breast cancer; HER2-negative metastatic or locally advanced unresectable BRCA-associated - first to third-line in combination with carboplatin and paclitaxel.
  • Non-squamous NSCLC, 1L.
  • Serous epithelial ovarian, fallopian tube or primary peritoneal cancer with BRCA1 mutation, stage III or IV high-grade - first-line with carboplatin and paclitaxel.
• Venetoclax in combinatie met rituximab
• Viable T-cells

Stofwisseling en Endocrinologie

• Abaloparatide
• Asfotase alfa
• Burosumab
• Cerliponase alfa
• Chenodeoxycholzuur
• Cholic acid
• Cinacalcet
• Cyclodextrine (Hydroxypropyl betadex)
• Dapagliflozine
• Enclomifene (citrate)
• Ertugliflozin
• Ertugliflozin (L-pyroglutamic acid) / metformin (hydrochloride)
• Ertugliflozin (L-pyroglutamic acid) / sitagliptin (phosphate monohydrate)
• Exenatide
• Glibenclamide
• Ibiglustat
• Idursulfase-IT
• Levamisole (hydrochloride)
• Lubiprostone
• Mercaptamine
• Metreleptin
• Migalastat
• Neod001
• Obeticholic acid
• Pasireotide LAR
• Patiromer
• Pegpleranib
• Pegvaliase
• Prasterone
• Recombinant parathyroid hormone
• Sebelipase alfa
• Semaglutide
• Sodium benzoate
• Sodium zirconium cyclosilicate
• Velmanase alfa
• Vestronidase alfa
• Volanesorsen (sodium)