Exenatide Medicine 09 January 2018 Extended indication Diabetes type 2 Therapeutic value Possible equal value Total cost Registration phase Unknown Product Active substance Exenatide Domain Metabolism and Endocrinology Reason of inclusion Main indication Diabetes Extended indication Diabetes type 2 Current proprietary name Already available biosimilars / generics Proprietary name Manufacturer Servier Portfolio holder Mechanism of action Unknown Route of administration Subcutaneous Therapeutical formulation Implant Budgetting framework Intermural (MSZ) Centre of expertise Additional remarks Subcutaan via osmotische minipomp. Registration Registration route Centralised (EMA) Type of trajectory Unknown Particularity Unknown ATMP Unknown Submission date Expected Registration Orphan drug No Registration phase Unknown Reimbursement Medicine sluice Additional remarks Therapeutic value Current treatment options Andere glp-1 analogen. Therapeutic value Possible equal value This assessment does not indicate any potential inclusion in the package. Substantiation Voordeel van deze toedieningsvorm is de lage toedieningsfrequentie. Dit pompje moet 1x/3 of 6 maanden sc worden ingebracht, in plaats van 1x/wk of 1dd sc injectie door patient zelf. Duration of treatment Frequency of administration 4 times a year Dosage per administration References Additional remarks Toediening 1 maal per 3 of 6 maanden. Expected patient volume per year Patient volume Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Additional remarks Een klein segment van de huidige glp-1 markt Expected cost per patient per year Cost References Additional remarks Laag financieel risico; als de NGH standaard diabetes glp-1 agonisten opneemt in het behandelalgoritme dan zal de commissie de voorkeur laten uitgaan naar middelen die een vermindering van cardiovasculaire events hebben laten zien. De cardiovasculaire outcome trial van dit middel heeft dat niet laten zien. Potential total cost per year Total cost Total cost for sluice Additional remarks Off label use Off label use No Indications off label use References Additional remarks Indication extension Indication extensions Unknown Indication extensions References Additional remarks Other information Additional remarks