Tradipitant Medicine 04 June 2026 Extended indication Tradipitant monotherapy for treatment of GLP-1R agonist-induced Nausea with vomiting in adults and elderly who are overweight or obese. Therapeutic value Total cost Registration phase Clinical trials Product Active substance Tradipitant Domain Metabolism and Endocrinology Reason of inclusion New medicine (specialité) Main indication Other metabolism and Endocrinology Extended indication Tradipitant monotherapy for treatment of GLP-1R agonist-induced Nausea with vomiting in adults and elderly who are overweight or obese. Current proprietary name Already available biosimilars / generics Proprietary name Nereus Manufacturer Vanda Portfolio holder Vanda Mechanism of action Receptor antagonist Route of administration Oral Therapeutical formulation Capsule Budgetting framework Extramural (GVS) Centre of expertise Additional remarks Neurokinin-1 (NK1) receptor antagonist Registration Registration route Centralised (EMA) Type of trajectory Particularity ATMP Submission date March 2027 Expected Registration April 2028 Orphan drug Registration phase Clinical trials Reimbursement Medicine sluice Additional remarks Tijdslijn op basis van IHSI-inschatting. Therapeutic value Current treatment options Anti-emetica: 5HT3-antagonisten, antihistaminica, antipsychotica, dopamine-antagonisten. Therapeutic value Substantiation Duration of treatment Frequency of administration Dosage per administration References NCT07446439 Additional remarks Expected patient volume per year Patient volume Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Additional remarks Expected cost per patient per year Cost € > 200.00 This amount gives an indication of the total cost. It is the result of the average expected patient volume times the average cost per patient. both per year. References https://nereus.us/ Additional remarks Er is geen Nederlandse lijstprijs bekend. In de Verenigde Staten is de lijstprijs $255 per capsule (ofwel €218,7). Potential total cost per year Total cost Total cost for sluice Additional remarks Off label use Off label use Indications off label use References Additional remarks Indication extension Indication extensions Indication extensions References Additional remarks Other information Additional remarks