Zanamivir Medicine 12 June 2018 Extended indication Influenza - treatment of hospitalised patients Therapeutic value No judgement Total cost € 435,000.00 Registration phase Registration application pending Product Active substance Zanamivir Domain Infectious diseases Reason of inclusion Main indication Viral infections other Extended indication Influenza - treatment of hospitalised patients Current proprietary name Already available biosimilars / generics Proprietary name Relenza Manufacturer GSK Portfolio holder Mechanism of action Unknown Route of administration Intravenous Therapeutical formulation Intravenous drip Budgetting framework Intermural (MSZ) Centre of expertise Additional remarks Betreft een nieuwe formulering als intraveneuze toediening. Neuraminidase inhibitor. Registration Registration route Centralised (EMA) Type of trajectory Unknown Particularity New medicine ATMP Unknown Submission date January 2018 Expected Registration February 2019 Orphan drug No Registration phase Registration application pending Reimbursement Medicine sluice Additional remarks Therapeutic value Current treatment options Oseltamivir Therapeutic value No judgement This assessment does not indicate any potential inclusion in the package. Substantiation Duration of treatment Average 5 day / days Frequency of administration 2 times a day Dosage per administration 600 mg References clinicaltrials.gov, NCT01527110 Additional remarks Expected patient volume per year Patient volume < 300 Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Additional remarks Inschatting werkgroep, maximaal 300 patiënten per jaar. Expected cost per patient per year Cost € 1,400.00 - 1,500.00 This amount gives an indication of the total cost. It is the result of the average expected patient volume times the average cost per patient. both per year. References Medicijnkosten.nl Additional remarks €4,85 voor een verpakking inhalers van 4 doses, 5 mg per dosis. Als het voor intraveneuze infusie een zelfde prijs zal worden komt dat neer op €1455 per patiënt per jaar. Potential total cost per year Total cost € 435,000.00 Total cost for sluice Additional remarks Off label use Off label use Unknown Indications off label use References Mogelijke inzet bij preventie van infectie met influenza. Additional remarks Indication extension Indication extensions No Indication extensions References Additional remarks Other information Additional remarks