Aflibercept Medicine 03 June 2025 Extended indication Aflibercept monotherapy for first line treatment of Macular oedema in adults and elderly secondary to retinal vein occlusion. Therapeutic value No estimate possible yet Total cost Registration phase Registration application pending Product Active substance Aflibercept Domain Neurological disorders Reason of inclusion Indication extension IND Main indication Eye disorders Extended indication Aflibercept monotherapy for first line treatment of Macular oedema in adults and elderly secondary to retinal vein occlusion. Current proprietary name Already available biosimilars / generics Proprietary name Eylea Manufacturer Bayer Portfolio holder Mechanism of action Unknown Route of administration Intravitreal Therapeutical formulation Injection Budgetting framework Intermural (MSZ) Centre of expertise Additional remarks Registration Registration route Centralised (EMA) Type of trajectory Unknown Particularity Unknown ATMP No Submission date April 2025 Expected Registration February 2026 Orphan drug No Registration phase Registration application pending Reimbursement Medicine sluice Additional remarks Therapeutic value Current treatment options Therapeutic value No estimate possible yet This assessment does not indicate any potential inclusion in the package. Substantiation Duration of treatment Frequency of administration Dosage per administration References NCT05850520 Additional remarks Expected patient volume per year Patient volume Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Additional remarks Expected cost per patient per year Cost € 3,500.00 This amount gives an indication of the total cost. It is the result of the average expected patient volume times the average cost per patient. both per year. References medicijnkosten.nl; GIPdatabank Additional remarks De prijs inclusief BTW: Eylea injectievloeistof 40mg/ml wwsp 0,09ml €788,85 per stuk. In 2021 bedroeg de gemiddelde vergoeding per patiënt per jaar €3.585. Potential total cost per year Total cost Total cost for sluice Additional remarks Off label use Off label use Unknown Indications off label use References Additional remarks Indication extension Indication extensions Unknown Indication extensions References Additional remarks Other information Additional remarks