Aflibercept Medicine 13 December 2018 Extended indication Diabetic macular edema Therapeutic value Possible equal value Total cost Registration phase Registered Product Active substance Aflibercept Domain Neurological disorders Reason of inclusion Biosimilar BS Main indication Eye disorders Extended indication Diabetic macular edema Current proprietary name Eylea (Bayer) Already available biosimilars / generics Proprietary name M-710 Manufacturer Momenta/Mylan Portfolio holder Mechanism of action Angiogenesis inhibitor Route of administration Unknown Therapeutical formulation Unknown Budgetting framework Intermural (MSZ) Centre of expertise Additional remarks Registration Registration route Centralised (EMA) Type of trajectory Unknown Particularity Unknown ATMP No Submission date May 2022 Expected Registration September 2023 Orphan drug No Registration phase Registered Reimbursement Medicine sluice Additional remarks Positieve CHMP-opinie juli 2023. SPC Eylea verloopt op 22 mei 2025. Therapeutic value Current treatment options Therapeutic value Possible equal value This assessment does not indicate any potential inclusion in the package. Substantiation Duration of treatment Frequency of administration Dosage per administration References Additional remarks Expected patient volume per year Patient volume Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Additional remarks Expected cost per patient per year Cost References Additional remarks Potential total cost per year Total cost Total cost for sluice Additional remarks Off label use Off label use Unknown Indications off label use References Additional remarks Indication extension Indication extensions Unknown Indication extensions References Additional remarks Other information Additional remarks