Brain cancer vaccine Medicine 09 January 2018 Extended indication Glioblastoma multiforme, 1L adjuvant. Therapeutic value No judgement Total cost Registration phase Clinical trials Product Active substance Brain cancer vaccine Domain Oncology and Hematology Reason of inclusion New medicine (specialité) Main indication Brain cancer Extended indication Glioblastoma multiforme, 1L adjuvant. Current proprietary name Already available biosimilars / generics Proprietary name DCVax-L Manufacturer Northwest Portfolio holder Mechanism of action Cancer vaccine Route of administration Intrader meal Therapeutical formulation Injection Budgetting framework Intermural (MSZ) Centre of expertise Additional remarks Registration Registration route Centralised (EMA) Type of trajectory Unknown Particularity Unknown ATMP Unknown Submission date Expected Registration Orphan drug Yes Registration phase Clinical trials Reimbursement Medicine sluice Additional remarks Dit geneesmiddel is geclassificeerd als een ATMP. Therapeutic value Current treatment options Therapeutic value No judgement This assessment does not indicate any potential inclusion in the package. Substantiation Duration of treatment Frequency of administration Dosage per administration References NCT00045968 Additional remarks Expected patient volume per year Patient volume 200 Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Expertopinie; IKNL Additional remarks In Nederland zijn er jaarlijks ongeveer 1.100 patiënten met de diagnose glioma waarbij er ongeveer 750 een pathologisch bevestigde diagnose glioblastoma krijgen. Voor een dergelijk vaccin zal er sprake moeten zijn van meer dan enkel een biopsie als diagnostische resectie. Over de jaren 2014-2017 is de verhouding biopt versus resectie 28,7% versus 71,3%. (215 versus 535 patiënten). Expected cost per patient per year Cost References Additional remarks Potential total cost per year Total cost Total cost for sluice Additional remarks Off label use Off label use Unknown Indications off label use References Additional remarks Indication extension Indication extensions No Indication extensions Lung Cancer Brain Metastases & Brain Metastases From Breast Cancer References clinicaltrials.gov Additional remarks Geen lopende fase 3 studies. Other information Additional remarks