Corabotase Medicine 04 June 2026 Extended indication Corabotase monotherapy for treatment of moderate to severe Glabellar frown lines in adults and elderly Therapeutic value Total cost Registration phase Clinical trials Product Active substance Corabotase Domain Neurological disorders Reason of inclusion New medicine (specialité) Main indication Neurological disorders other Extended indication Corabotase monotherapy for treatment of moderate to severe Glabellar frown lines in adults and elderly Current proprietary name Already available biosimilars / generics Proprietary name Manufacturer Ipsen Portfolio holder Ipsen Mechanism of action Neurotoxin Route of administration Intramuscular Therapeutical formulation Injection Budgetting framework Extramural (GVS) Centre of expertise Additional remarks Registration Registration route Centralised (EMA) Type of trajectory Particularity ATMP Submission date March 2027 Expected Registration April 2028 Orphan drug Yes Registration phase Clinical trials Reimbursement Medicine sluice Additional remarks Tijdslijn op basis van IHSI-inschatting. Therapeutic value Current treatment options Botulinum A toxin Therapeutic value Substantiation Duration of treatment Frequency of administration Dosage per administration References NCT07435428, NCT07427797 Additional remarks Expected patient volume per year Patient volume Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Additional remarks Expected cost per patient per year Cost References Additional remarks Er is nog geen lijstprijs bekend voor corabotase. De lijstprijs van Dysport bedraagt €188,10 (exclusief BTW) per 500 eenheden. Bij het bepalen van de budgetimpact dient rekening te worden gehouden met een berekening van equivalente eenheden wanneer wordt vergeleken met andere botulinetoxine A producten. Potential total cost per year Total cost Total cost for sluice Additional remarks Off label use Off label use Indications off label use References Additional remarks Indication extension Indication extensions Indication extensions References Additional remarks Other information Additional remarks