Nivolumab Medicine 09 January 2018 Extended indication Metastatic colorectal carcinoma with mismatch-repair deficient (dMMR) microsatellite instability–high (MSI-H). Therapeutic value No judgement Total cost Registration phase Withdrawn Product Active substance Nivolumab Domain Oncology and Hematology Reason of inclusion Main indication Colon cancer Extended indication Metastatic colorectal carcinoma with mismatch-repair deficient (dMMR) microsatellite instability–high (MSI-H). Current proprietary name Already available biosimilars / generics Proprietary name Opdivo Manufacturer BMS Portfolio holder Mechanism of action Unknown Route of administration Unknown Therapeutical formulation Unknown Budgetting framework Unknown Centre of expertise Additional remarks Registration Registration route Unknown Type of trajectory Unknown Particularity Indication extension ATMP Unknown Submission date Expected Registration Orphan drug Unknown Registration phase Withdrawn Reimbursement Medicine sluice Additional remarks Registratieaanvraag teruggetrokken door de fabrikant in januari 2018. Therapeutic value Current treatment options Therapeutic value No judgement This assessment does not indicate any potential inclusion in the package. Substantiation Duration of treatment Frequency of administration Dosage per administration References Additional remarks Expected patient volume per year Patient volume Market share is generally not included unless otherwise stated. Maximum patient volume for sluice References Additional remarks Expected cost per patient per year Cost References Additional remarks Potential total cost per year Total cost Total cost for sluice Additional remarks Off label use Off label use Unknown Indications off label use References Additional remarks Indication extension Indication extensions Unknown Indication extensions References Additional remarks Other information Additional remarks