Extended indication Advanced urothelial cancer, second line.
Therapeutic value Possible equal value
Total cost 0.00
Registration phase No registration expected

Product

Active substance Ramucirumab
Domain Oncology and Hematology
Reason of inclusion Indication extension
Main indication Bladder cancer
Extended indication Advanced urothelial cancer, second line.
Proprietary name Cyramza
Manufacturer Eli Lilly
Route of administration Intravenous
Therapeutical formulation Intravenous drip
Budgetting framework Intermural (MSZ)
Additional comments Anti-VEGF receptor 2 antibody.

Registration

Registration route Centralised (EMA)
Orphan drug No
Registration phase No registration expected
Additional comments Update fabrikant: Hiervoor wordt geen registratie aangevraagd

Therapeutic value

Current treatment options Sinds kort immunotherapie
Therapeutic value Possible equal value
Duration of treatment Median 12 week / weeks
Frequency of administration 2 times a month
Dosage per administration 10 mg/kg
References Petrylak et al. Lancet. 2017 Nov 18;390(10109):2266-2277
Additional comments Behandelschema: 12 weken/4 toedieningen; 1 maal per 3 weken.

Expected patient volume per year

Additional comments De verwachting is dat met de introductie van immunotherapie deze behandeling niet tot vrijwel niet zal worden voorgeschreven.

Expected cost per patient per year

Cost 15,000.00 - 20,000.00
References Medicijnkosten.nl
Additional comments Meerkosten. Bij aantal toedieningen van vier; 75 kg gewicht; 10 mg/kg; betekent zes ampullen 10 mg/l van 50 ml: €17.171,94.

Potential total cost per year

Total cost

0.00

This amount gives an indication of the total cost. It is the result of the average expected patient volume times the average cost per patient. both per year.

Off label use

Off label use No

Indication extension

Indication extension No

Other information

There is currently no futher information available.