Neurological disorders

ADHD

• Dexmethylphenidate

ALS

• Cnm-au8
• Lenzumestrocel

Dementia

• Blarcamesine
• Donanemab
• Lecanemab
• Masupirdine

Depression

• Psilocybine
• Seltorexant
• Zuranolone

Duchenne

• Casimersen
• Delpacibart zotadirsen
• Deramiocel

• Givinostat

  • Duvyzat is indicated for the treatment of Duchenne muscular dystrophy (DMD) in ambulant patients, aged 6 years and older, and with concomitant corticosteroid treatment.
• Golodirsen

• Vamorolone

  • Agamree is indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients aged 2 years and older.

Epilepsy

• Bexicaserin
• Cannabis Extract Ycj-01

• Cenobamaat

  • Cenobamate monotherapy for adjunctive treatment of primary generalised tonic-clonic seizure in adolescents, adults and elderly with idiopathic generalised epilepsy

• Fenfluramine

  • Dravet Syndroom < 2 jaar
  • CDKL5 syndroom
• Opakalim
• Zonisamide ^IND

Eye disorders

• AVD-104
• Aceclidine
• Acoltremon
• Atropinesulfaat ^IND
• Brimonidine tartrate/carbachol
• Citicoline
• IBI311
• Midazolam/ketamine
• OCU400

• Ranibizumab

  • Treatment of diabetic macular edema (DME).
  • Treatment of neovascular age-related macular degeneration (AMD).
• Revakinagene Taroretcel
• Ripasudil
• Sonpiretigene Isteparvovec

• Tarcocimab tedromer

  • Macular edema due to retinal vein occlusion (RVO).
• Tinlarebant ^G
• Vamikibart

Headache

• Atogepant

  • Acute treatment of migraine with or without aura in adults

• Botulinetoxine-A

  • Btx-a monotherapy for preventive treatment of episodic Migraine in adults and elderly
  • Btx-a monotherapy for preventive treatment of chronic Migraine in adults and elderl

• Eptinezumab

  • Eptinezumab monotherapy for preventive treatment of with or without aura chronic Migraine in adolescents.

• Fremanezumab

  • Fremanezumab monotherapy for preventive treatment of Chronic migraine, Episodic migraine in children over 6 years of age and adolescents.

Multiple sclerosis

• Fenebrutinib

  • Relapsing MS
  • Primair progressieve MS (PPMS)

• Ocrelizumab

  • Pediatrische patiënten van tien jaar en ouder met relapsing remitting MS (RRMS)
• Tolebrutinib

Muscular diseases other

• Baclofen / naltrexone / sorbitol
• Condoliase
• Doxecitine / doxiribtimine
• Empasiprubart
• Iltamiocel
• Incobotulinumtoxina

• Inebilizumab

  • Uplizna is indicated as an add-on to standard therapy for the treatment of gMG in adult patients who are anti-acetylcholine receptor (AChR) or anti-muscle-specific tyrosine kinase (MuSK) antibody positive (see section 5.1).
• Kyv-101
• Mexiletine ^IND
• Nipocalimab
• Nomlabofusp
• Sevasemten

• Sugammadex

  • Extension of indication to include treatment the paediatric population: sugammadex is only recommended for routine reversal of rocuronium induced blockade in paediatric patients from birth to 17 years.
• Tanruprubart
• Vatiquinone

Neurological disorders other

• Corabotase
• Deutetrabenazine (extended release)
• Diflunisal
• Ecopipam
• Efgartigimod alfa ^IND
• Gefurulimab

• L-acetylleucine

  • Levacetylleucine monotherapy for treatment of Ataxia telangiectasia in children over 4 years of age, adolescents, adults and elderly
• Nepla-tem-cel

• Tiratricol

  • Emcitate is indicated for the treatment of peripheral thyrotoxicosis in patients with monocarboxylate transporter 8 (MCT8) deficiency (Allan-Herndon-Dudley Syndrome), from birth.
• TrenibotulinumtoxinE
• Trofinetide
• Ulixacaltamide
• Zilganersen

Other psychiatry

• Soclenicant

Pain

• Adezunap
• Basimglurant
• Chloroprocaine ^IND
• Cipepofol
• Sufentanil / ketamine

Parkinson's

• Levodopa / carbidopa

  • Onerji is indicated for the treatment of motor fluctuations in patients with advanced Parkinsonʼs disease which are not sufficiently controlled by oral anti-Parkinson medicinal products.

SMA

• Apitegromab

• Nusinersen

  • Nusinersen monotherapy for treatment of 5q Spinal muscular atrophy in newborns, infants, toddlers, children, adolescents and adults administered at a higher dose.

• Onasemnogene abeparvovec

  • Itvisma is indicated for the treatment of 5q spinal muscular atrophy (SMA) with a bi-allelic mutation in the SMN1 gene in patients 2 years of age and older

Schizophrenia, psychosis, bipolar disorder

• BHV-7000
• Brexpiprazol ^IND
• Evenamide
• Iloperidon
• Olanzapine (long-acting injectable)

Sleep disorders

• Lemborexant
• Oveporexton